Recommended name. Iduronate 2-sulfatase [. EC 3.1.6.13. ] Alternative name. Alpha-L-iduronate sulfate sulfatase Short: Idursulfase. Cleaved into the following 2 chains. Iduronate 2-sulfatase 14 kDa chain. Iduronate 2-sulfatase 42 kDa chain.
Enzyme levels may be normal in individuals receiving enzyme replacement therapy or who have undergone bone marrow transplant. Iduronate-2-sulfatase can also be deficient in individuals with multiple sulfatase deficiency.
The deficiency of 8 Sep 2017 He, Qi Qi (2017). Synthesis of potential inhibitors of iduronate-2-sulfatase as pharmacological chaperones for MPS II and development of 19 Oct 2020 Introduction: Mucopolysaccharidosis type II (MPS-II) or Hunter syndrome is a rare Sequence of the human iduronate 2-sulfatase (IDS) gene. Disclosed are a composition comprising recombinant iduronate-2-sulfatase (IDS) and a method for treating Hunter syndrome. The glycosylation pattern and Hunter syndrome (Mucopolysaccharidosis type II, MPS2) is an X-linked recessively inherited disease caused by a deficiency of iduronate 2 sulfatase ( IDS). 6 Feb 2021 Iduronate 2-sulfatase (IDS) is responsible for the breakdown of large sugar molecules called glycosaminoglycans.
6 Feb 2021 Iduronate 2-sulfatase (IDS) is responsible for the breakdown of large sugar molecules called glycosaminoglycans. Decreased activity of IDS Iduronate 2 sulfatase antibody Mouse Monoclonal from Proteintech validated in Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) 30 Jan 2020 Hunter's syndrome (mucopolysaccharidosis type II) is a rare X-linked disorder caused by mutations in the iduronate-2-sulfatase (IDS) gene. It is a purified form of the lysosomal enzyme iduronate-2-sulfatase and is produced by by Shire, is a drug used to treat Hunter syndrome (also called MPS-II). Instinct® II nitrogen stabilizer optimizes corn and wheat yield by inhibiting nitrification of applied nitrogen with UAN, urea and liquid manure. Item 1 - 10 of 274 A 2 Well Culture-Insert for wound healing and migration assays | Defined cell- free gap for reproducible experiments | Alternative to scratch 2.1 mg atropine in 0.7 mL and 600 mg pralidoxime chloride in 2 mL sequentially through a single needle using the two-chambered BinaJect® drug delivery system (enasidenib) is indicated for the treatment of adult patients with relapsed or refractory (R/R) acute myeloid leukemia (AML) with an isocitrate dehydrogenase- 2 9 Dec 2019 Fusidic acid is used for skin infections such as impetigo and dermatitis. You can learn more about fusidic acid, including side effects and Courtney D. DiNardo, MD, MSCE:There are 2 differentIDH2mutations.
The present invention provides a highly glycosylated iduronate-2-sulfatase enzyme comprising an iduronate-2-sulfatase polypeptide with at least 5 kilodalton (kDa) more sugar than iduronate-2-sulfatase purified from a natural source, e.g. human liver.
Iduronate 2-sulfatase [. EC 3.1.6.13. ] Alternative name. Alpha-L-iduronate sulfate sulfatase Short: Idursulfase.
The first deletion, corresponding to a loss of 3152 bp of DNA, included exons 5 and 6 of the iduronate-2-sulfatase (IDS) gene. The second deletion was 3603 bp
Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Enzyme levels may be normal in individuals receiving enzyme replacement therapy or who have undergone bone marrow transplant. Iduronate-2-sulfatase can also be deficient in individuals with multiple sulfatase deficiency. Iduronate-2-sulfatase is required for the lysosomal degradation of heparan sulfate and dermatan sulfate.
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Mucopolysaccharidosis type II or Hunter syndrome is a rare lysosomal storage disorder caused by a deficiency in the enzyme iduronate-2-sulfatase (IDS). alfa, INN, Engelska.
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1999 Jan;36(1):21-7.
The symptoms of Hunter syndrome are comparable to those of MPS I
The report on Global Iduronate 2 Sulfatase Market offers in-depth analysis on market trends, drivers, restraints, opportunities etc.
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Institute for the Study of Inborn Errors of Metabolism, Faculty of Science, Pontificia Universidad Javeriana, Bogotá, Colombia.
DiNatale and Ronsisvalle (1981) identified 2 forms of iduronate sulfatase from human placenta and Bielicki et al. (1990) purified 2 major forms with molecular masses of 42 kD and 14 kD from human liver. Wilson et al. (1990) isolated and sequenced a 2.3-kb cDNA clone coding for the entire sequence of human IDS from an endothelial cell cDNA library.
EC 3.1.6.13. CAS No. This product was previously labelled as Iduronate 2 sulfatase . The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation.
Iduronate 2-Sulfatase/IDS: Products. Sulfatases belong to a highly conserved family of enzymes that catalyze the hydrolysis of O- and N-sulfate esters from a variety of substrates. Among 18 human sulfatase genes identified, about 1/3 are found in lysosomes and serve to remove sulfate from glycosaminoglycans (GAGs), glycopeptides and glycolipids Our Iduronate 2-Sulfatase/IDS Antibodies can be used in a variety of model species: Canine, Human, Monkey, Mouse, Rat. Use the list below to choose the Iduronate 2-Sulfatase/IDS Antibody which is most appropriate for your research; you can click on each one to view full technical details, images, references, reviews and related products. Demonstration of deficient iduronate-2-sulfatase enzyme activity is considered the gold standard to confirm a diagnosis of Mucopolysaccharidosis II (MPS II), Hunter Syndrome. In addition, it can be used to clarify molecular findings in the IDS gene and to follow up abnormal newborn screening results.